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95 Newest Publications about the topic warfarin


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Cosolubilization of Coumarin30 and Warfarin in Cationic, Anionic, and Nonionic Micelles: A Micelle–Water Interfacial Charge Dependent FRET

17-Aug-2015 | Aijaz Ahmad Dar; Oyais Ahmad Chat, Journal of Physical Chemistry B, 2015

Solubilization of structurally varied coumarins, viz., Warfarin (WF; a 4-hydroxy coumarin) and Coumarin30 (C30, a 7-amino coumarin) individually and in mixed states (cosolubilization) within the aqueous surfactant self-assemblies of varying architectures has been explored, exploiting ...


Fe3O4 Nanoparticles as Highly Efficient and Recyclable Catalyst for the Synthesis of 4-Hydroxy-3-[aryloyl(benzamido)methyl]coumarin under Solvent-Free Conditions

21-Jul-2015 | Khodabakhshi, Saeed; Khaleghi Abbasabadi, Masoud; Heydarian, Samaneh; Gharehzadeh Shirazi, Sanaz; Marahel, Farzaneh, Letters in Organic Chemistry, 2015

Abstract: A clean, efficient and facile one-pot protocol was developed for the synthesis of a series of new 3,4-substituted coumarins (warfarin analogous compounds) by a one-pot reaction using catalytic amount of Fe3O4 nanoparticles under solvent-free conditions. This green method offers ...


Effect of DOM Size on Organic Micropollutant Adsorption by GAC

22-May-2015 | Anthony M. Kennedy; R. Scott Summers, Environmental Science & Technology, 2015

Granular activated carbon (GAC) adsorption of the micropollutants 2-methylisoborneol (MIB) and warfarin (WFN) at ng/L levels was investigated in five waters with isolated natural dissolved organic matter (DOM) held at a constant dissolved organic carbon concentration. Each water was evaluated for ...


Cardiovascular Effects of Coumarins Besides their Antioxidant Activity

16-Apr-2015 | Najmanova, Iveta; Dosedel, Martin; Hrdina, Radomir; Anzenbacher, Pavel; Filipsky, Tomas; Riha, Michal; Mladenka, Premysl, Current Topics in Medicinal Chemistry, 2015

Abstract: Coumarins are a large group of substances, primarily of plant origin. Like their more intensively examined congeners flavonoids, many of them are antioxidants. Although such properties may be advantageous in cardiovascular diseases, it has been shown that coumarins exhibit direct ...


ChemInform Abstract: Zinc Oxide Nanorods: A New Application as a Powerful Catalyst for the Green One‐Pot Synthesis of New Warfarin Analogues.

26-Mar-2015 | Fariba Jafari, Saeed Kodabakhshi, Sanaz Gharehzadeh Shirazi, ChemInform, 2015

Abstract The catalyst is recycled and reused in three additional cycles without significant loss of its activity.


Warfarin Dosage Response Related Pharmacogenetics in Chinese Population

16-Jan-2015 | Siyue Li et al., PLoS ONE, 2015

by Siyue Li, Yuangao Zou, Xia Wang, Xunbei Huang, Yong Sun, Yuqing Wang, Li Dong, Hong Jiang Objectives As the most frequently prescribed anticoagulant, warfarin has large inter-individual variability in dosage. Genetic polymorphisms could largely explain the differences in dosage requirement. ...


ChemInform Abstract: Asymmetric Synthesis of Warfarin and Its Analogues on Water.

27-Nov-2014 | Maria Rogozinska‐Szymczak, Jacek Mlynarski, ChemInform, 2014

Abstract (S,S)‐Diphenylethylenediamine is demonstrated to be an excellent organocatalyst for the enantioselective Michael addition of 4‐hydroxycoumarins to α,β‐unsaturated ketones.


Lipase‐Supported Metal–Organic Framework Bioreactor Catalyzes Warfarin Synthesis

10-Nov-2014 | Wan‐Ling Liu, Ni‐Shin Yang, Ya‐Ting Chen, Stephen Lirio, Cheng‐You Wu, Chia‐Her Lin, Hsi‐Ya Huang, Chemistry - A European Journal, 2014

Abstract A green and sustainable strategy synthesizes clinical medicine warfarin anticoagulant by using lipase‐supported metal–organic framework (MOF) bioreactors (see scheme). These findings may be beneficial for future studies in the industrial production of chemical, pharmaceutical, and ...


Development of apixaban: a novel anticoagulant for prevention of stroke in patients with atrial fibrillation

05-Nov-2014 | Michael S. Hanna, Puneet Mohan, Robert Knabb, Elora Gupta, Charles Frost, John H. Lawrence, Annals of the New York Academy of Sciences, 2014

The factor Xa inhibitor apixaban is one of the novel anticoagulants to emerge as alternatives to long‐standing standards of care that include low‐molecular‐weight heparin and warfarin. The development of apixaban reflects a strategy to optimize the clinical pharmacology profile, dosing posology, ...


Binding of Doxyl Stearic Spin Labels to Human Serum Albumin: An EPR Study

09-Sep-2014 | Aleksandra A. Pavićević; Ana D. Popović-Bijelić; Miloš D. Mojović; Snežana V. Šušnjar; Goran G. Bačić, Journal of Physical Chemistry B, 2014

The binding of spin-labeled fatty acids (SLFAs) to the human serum albumin (HSA) examined by electron paramagnetic resonance (EPR) spectroscopy was studied to evaluate the potential of the HSA/SLFA/EPR technique as a biomarking tool for cancer. A comparative study was performed on two spin labels ...


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