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While brucine is related to strychnine, it is not as poisonous. Nevertheless, a human consuming over 2 milligrams of pure brucine will almost certainly suffer symptoms resembling strychnine poisoning.
Medically, brucine is primarily used in the regulation of high blood pressure and other comparatively benign cardiac ailments. It is cultivated commercially in some parts of the United States and European Union.
Wikisource has the text of the 1911 Encyclopædia Britannica article Brucine.
The alkaloid brucine is isostructural to strychnine with methoxy groups at the aromatic ring rather than hydrogens (positions 9 and 10). Both brucine and strychnine are commonly used as agents for chiral resolution. The separation of racemic mixtures by alkaloids from the cinchona bark has been known since 1853 when its use as such was reported by Pasteur. The ability of brucine, and to a lesser extent strychnine, to function as resolving agents for amino acids was reported by Fisher in 1899. Brucine and strychnine are basic and thus have a tendency to crystallise with acids. The acid-base reaction leaves the brucine protonated at the N(2) position. The formation of diastereomeric salts has been reported for thousands of organic compounds. The packing of brucine in corrugated (waving) layers was an essential aspect in the co-crystallisation of brucine, whereas strychnine was shown to crystallise predominantly in bilayers.
Perhaps the best-known reference to brucine occurs in The Count of Monte Cristo, the novel by French author Alexandre Dumas, père:
Brucine was also mentioned in the movie The Mechanic, starring Charles Bronson. In this 1972 film, aging hitman Arthur Bishop (Bronson) takes young Steve McKenna (Jan-Michael Vincent) under his wing and the two team up as hitmen. McKenna betrays Bishop in the end by offering Bishop a celebratory glass of wine that has been spiked with brucine, leaving Bishop to die of what appears to be a heart attack.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Brucine". A list of authors is available in Wikipedia.|