Topic world Synthesis

Chemical synthesis is at the heart of modern chemistry and enables the targeted production of molecules with specific properties. By combining starting materials in defined reaction conditions, chemists can create a wide range of compounds, from simple molecules to complex active ingredients.

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Synthesis explained

Chemical synthesis

Chemical synthesis In chemistry , chemical synthesis is purposeful execution of chemical reaction s in order to get a product , or several products. This happens by physical and chemical manipulations usually involving one or more reactions. In modern laboratory usage, this tends to imply that the ...

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Hantzsch pyridine synthesis

Hantzsch pyridine synthesis The Hantzsch pyridine synthesis or Hantzsch dihydropyridine synthesis is a multi-component organic reaction between an aldehyde such as formaldehyde , 2 equivalents of a β-keto ester such as ethyl acetoacetate and a nitrogen donor such as ammonium acetate or ammon ...

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Hemetsberger indole synthesis

Hemetsberger indole synthesis The Hemetsberger indole synthesis (also called the Hemetsberger-Knittel synthesis) is a chemical reaction that thermally decomposes a 3-aryl-2-azido-propenoic ester into an indole -2-carboxylic ester . Yields are typically above 70%. However, this is not a popular ...

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Hydrothermal synthesis

Hydrothermal synthesis crystal grown by the hydrothermal method Hydrothermal synthesis includes the various techniques of crystallizing substances from high-temperature aqueous solution s at high vapor pressure s; also termed "hydrothermal method". The term "hydrothermal " is of geologic origin. G ...

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Knorr quinoline synthesis

Knorr quinoline synthesis The Knorr quinoline synthesis is an intramolecular organic reaction converting a β-ketoanilide to a 2-hydroxyquinoline using sulfuric acid . This reaction was first described by Ludwig Knorr (1859 - 1921) in 1886 The reaction is a type of electrophilic aromatic ...

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Kuwajima Taxol total synthesis

Kuwajima Taxol total synthesis overview from raw material perspectiveThe Kuwajima Taxol total synthesis by the group of Isao Kuwajima of the Tokyo Institute of Technology is one of several efforts in taxol total synthesis published in the 1990's . The total synthesis of Taxol is considered a ...

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Leimgruber-Batcho indole synthesis

Leimgruber-Batcho indole synthesis The Leimgruber-Batcho indole synthesis is a series of organic reaction s that produce indole s from o-nitrotoluene s 1. The first step is the formation of an enamine 2 using N,N-dimethylformamide dimethyl acetal and pyrrolidine . The desired indole 3 is then fo ...

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Retrosynthetic analysis

Retrosynthetic analysis Retrosynthetic analysis is a technique for solving problems in the planning of organic syntheses . This is achieved by transforming a target molecule into simpler precursor structures without assumptions regarding starting materials. Each precursor material is examined using ...

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Weinreb ketone synthesis

Weinreb ketone synthesis The Weinreb ketone synthesis is a chemical reaction used to transform N,O-dimethylhydroxamic acids (Weinreb amides, 1) into ketone s (3). Addition of the organometallic nucleophile to the Weinreb amide produces a stable tetrahedral chelate (2), which upon hydrolysis pro ...

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