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2-Methoxyestradiol



2-Methoxyestradiol
Systematic (IUPAC) name
(8R,9S,13S,14S,17S)-2-methoxy-
13-methyl-6,7,8,9,11,12,14,15,16,17-
decahydrocyclopenta[a]phenanthrene-3,17-diol
Identifiers
CAS number 362-07-2
ATC code  ?
PubChem 66414
Chemical data
Formula C19H26O3 
Mol. mass 302.408 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It is derived from estrogen, although it binds poorly to known estrogen receptors, and belongs to the family of drugs called angiogenesis inhibitors. It has undergone Phase 1 clinical trials against breast cancers. Preclinical models also suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. The CAS name for 2ME2 is (17 beta)-2-methoxyestra-1,3,5(10)-triene-3,17-diol. It also acts as a vasodilator.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "2-Methoxyestradiol". A list of authors is available in Wikipedia.
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