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3,4-Diaminopyridine is an experimental drug used in the treatment of Lambert-Eaton Syndrome. In Lambert-Eaton Syndrome, acetylcholine release is inhibited as antibodies meant to target characteristic cancers target Ca2+ channels on the prejunctional membrane instead. 3,4-Diaminopyridine works by blocking potassium channel efflux in nerve terminals so that action potential duration is increased. Ca2+ channels can then be open for longer time and allow greater acetylcholine release to stimulate muscle at end plate.
Additional recommended knowledge
It has also been proposed for use in multiple sclerosis.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "3,4-Diaminopyridine". A list of authors is available in Wikipedia.|