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Additional recommended knowledge
Morpholinos have been tested for a wide range of applications including prevention of cardiac restenosis after angioplasty, treatment of coronary artery bypass grafts, treatment of polycystic kidney disease, and redirection of drug metabolism. Morpholinos have been used in preclinical studies to inhibit replication of West Nile Virus, SARS, Hepatitis C, dengue fever, Ebola and Calicivirus, all of which are single stranded RNA viruses. However, clinical studies have not demonstrated significant effects in humans and there are no approved drugs in this class.
In addition to development of Morpholinos as therapeutics, AVI has conducted six human trials for colorectal and pancreatic cancers using their cancer vaccine AVICINE.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "AVI_BioPharma". A list of authors is available in Wikipedia.|