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The Aldol-Tishchenko reaction is a tandem reaction involving an Aldol reaction and a Tishchenko reaction. In organic synthesis it is a method to convert aldehydes and ketones into 1,3-hydroxyl compounds. The reaction sequence in many examples starts from conversion of a ketone into an enolate by action of Lithium diisopropylamide (LDA). The mono-ester diol is then converted into the diol by a hydrolysis step. With both the acetyl trimethylsilane  and propiophenone  as reactants, the diol is obtained as a pure diastereoisomer.
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|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Aldol-Tishchenko_reaction". A list of authors is available in Wikipedia.|