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Alpha-7 nicotinic receptor



The alpha-7 nicotinic receptor (α7)5 is a type of nicotinic acetylcholine receptor, consisting entirely of α7 subunits [1].

Additional recommended knowledge

It is located in the brain, where activation yields post- and presynaptic excitation[1], mainly by increased Ca2+ permeability.

Agonists

Nicotinic agonists for this receptor include:

Antagonists

alpha-conotoxin ArIB[V11L,V16D][2]

2. Whiteaker P, Christensen S, Yoshikami D, Dowell C, Watkins M, Gulyas J, Rivier J, Olivera BM, McIntosh JM. Discovery, synthesis, and structure activity of a highly selective alpha7 nicotinic acetylcholine receptor antagonist. Biochemistry. 2007 Jun 5;46(22):6628-38.

  1. ^ a b Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0443071454, 5:th ed., Churchill Livingstone 2003) Page 138.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Alpha-7_nicotinic_receptor". A list of authors is available in Wikipedia.
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