Antimicrobial pharmacodynamics

Antimicrobial pharmacodynamics is a term used to describe the relationship between concentration of antibiotic and the observed antimicrobial effect.^[1] In pharmacodynamics the study of the biochemical and physiological examining effects of drugs and the mechanisms of drug action and the relationship between drug concentration and a general effect. In comparison antimicrobial pharmacodynamics which also relates concentration of an anti-infective agent to effect, but specifically to its antimicrobial effect.^[2]

Additional recommended knowledge

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Concentration-dependant effects

The minimum inhibitory concentration and minimum bactericidal concentration are used to measure in vitro activity antimicrobial and is an excellent indicator of antimicrobial potency. They dont give any information relating to time-dependant antimicrobial killing the so called post antibiotic effect.^[1]

References

1. ^ ^{a b} C.H. Nightingale, T. Murakawa, P.G. Ambrose (2002) Antimicrobial Pharmacodynamics in Theory and Clinical Practice Informa Health Care ISBN 0824705610
2. ^ Drusano GL (2004). "Antimicrobial pharmacodynamics: critical interactions of 'bug and drug'". Nat. Rev. Microbiol. 2 (4): 289–300. doi:10.1038/nrmicro862. PMID 15031728.