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Base analog

A base analog is a chemical that can substitute for a normal nucleobase in nucleic acids.

A common example would be 5-bromouracil (5BU), the abnormal base found in the mutagenic nucleotide analog BrdU. When a nucleotide containing 5-bromouracil is incorporated into the DNA, it is most likely to pair with adenine; however, it can spontaneously shift into another isomer which pairs with a different nucleobase, guanine. If this happens during DNA replication, a guanine will be inserted opposite the base analog, and in the next DNA replication, that guanine will pair with a cytosine. This results in a change in one base pair of DNA, specifically a transition mutation.


See also


  • Griffiths AJ, Wessler SR, Lewontin RC, Gelbart WM, Suzuki DT, Miller JH. Introduction to Genetic Analysis, 8th ed. New York:W.H.Freeman and Co, 2005.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Base_analog". A list of authors is available in Wikipedia.
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