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Benfotiamine


Benfotiamine
Systematic (IUPAC) name
S-[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl- formylamino]-5-phosphonooxypent-2-en-3-yl] benzenecarbothioate
Identifiers
CAS number	22457-89-2
ATC code	A11DA03
PubChem	3032771
Chemical data
Formula	C₁₉H₂₃N₄O₆P S
Mol. mass	466.449 g/mol
Synonyms	S-benzoylthiamine-O-monophosphate
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Benfotiamine (rINN, also known as benfotiamine or benphothiamine) is an allithiamin, a naturally-occurring lipophilic form of thiamine. The primary use of this antioxidant is as an "anti-age" supplement. However, in Germany doctors have been known to combine benfotiamine with pyridoxine hydrochloride and use it to treat patients with nerve damage and nerve pain such as sciatica.

v • d • e Vitamins (A11)
fat soluble	A (Retinol, Beta-carotene, Tretinoin, Alpha-carotene) - D (Ergocalciferol, Cholecalciferol, Dihydrotachysterol, Calcitriol, Calcidiol) - E (Tocopherol, Tocotrienol) - K (Naphthoquinone, Phylloquinone/K1, Menatetrenone/K2)
water soluble: B vitamins	B₁ (Thiamine, Sulbutiamine, Benfotiamine) - B₂ (Riboflavin) - B₃ (Niacin, Nicotinamide) - B₅ (Pantothenic acid, Dexpanthenol, Pantethine) - B₆ (Pyridoxine, Pyridoxal phosphate) - B₇ (Biotin) - B₉ (Folic acid) - B₁₂ (Cyanocobalamin, Hydroxocobalamin, Methylcobalamin, Cobamamide)
water soluble: other	C (Ascorbic acid) - Choline

Additional recommended knowledge

Essential Laboratory Skills Guide

What is the Correct Way to Check Repeatability in Balances?

Daily Sensitivity Test

Benfotiamine has shown to be an effective intervention for the treatment of diabetic retinopathy, neuropathy, and nephropathy, possibly because Benfotiamine is a transketolase activator that directs advanced glycation and lipoxidation end products (AGE's, ALE's) substrates to the pentose phosphate pathway, thus reducing tissue AGEs.

Categories: Amines | B vitamins | Pyrimidines