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Benserazide



Benserazide
Systematic (IUPAC) name
2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)
methyl]propanehydrazide
Identifiers
CAS number 14919-77-8
ATC code  ?
PubChem 2327
Chemical data
Formula C10H15N3O5 
Mol. mass 293.71 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion Renal and fecal
Therapeutic considerations
Pregnancy cat.

B3(AU)

Legal status

POM(UK) (with levodopa)

Routes  ?

Benserazide is an inhibitor of DOPA decarboxylase that does not enter the central nervous system. It is often given in combination with L-DOPA (levodopa) as Co-Beneldopa (BAN) (e.g. Madopar® by Roche in UK) in the treatment of Parkinson's disease to prevent the conversion of L-DOPA to dopamine in the periphery (due to its molecular size it can not penetrate the blood brain barrier) the amount that reaches the central nervous system and reducing the required dose, and also decreasing side effects due to the presence of dopamine in the system (outside of the central nervous system). It has no antiparkinson actions when given alone.

Additional recommended knowledge


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Benserazide". A list of authors is available in Wikipedia.
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