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The Blaise reaction is an organic reaction that forms a β-ketoester from the reaction of zinc metal with a α-bromoester and a nitrile. The final intermediate is a metaloimine, which is hydrolyzed to give the desired β-ketoester.
Additional recommended knowledge
Bulky aliphatic esters tend to give higher yields. Hannick and Kishi have developed an improved procedure.
It has been notedthat free hydroxyl groups can be tolerated in the course of this reaction, which is surprising for reactions of organometal halides.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Blaise_reaction". A list of authors is available in Wikipedia.|