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CASP, which stands for Critical Assessment of Techniques for Protein Structure Prediction, is a community-wide experiment (though it is commonly referred to as a competition) for protein structure prediction taking place every two years since 1994.
Additional recommended knowledge
CASP provides research groups with an opportunity to assess the quality of their methods for protein structure prediction from the primary structure of the protein. As a consequence, CASP provides the research community with an assessment of the state of the art in this field. It is not uncommon for entire research groups to shut down for months while they focus on getting their results ready for CASP.
Protein structures that are either expected to be solved shortly or that have been recently solved, but not yet discussed in public, are used as targets for the prediction. If the given sequence is found (for example, using sequence alignment methods such as BLAST or FASTA) to be similar to a protein sequence of known structure, comparative protein modeling may be used to predict the tertiary structure. Otherwise, other methods such as protein threading or de novo protein structure prediction must be applied.
Evaluation of the results is carried out in the following prediction categories:
Tertiary structure prediction category was further subdivided into
Starting CASP7, categories have been redefined to reflect developments in methods. The 'Template based modeling' category includes all former comparative modeling, homologous fold based models and some analogous fold based models. The 'Template free modeling' category includes models of proteins with previously unseen folds and hard analogous fold based models.
The CASP results are published in special issues of the scientific journal Proteins: , , , , 
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CASP". A list of authors is available in Wikipedia.|