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Cafestol




Cafestol
Systematic (IUPAC) name
(3bS,5aS,7R,8R,10aS,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro-
7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol
Identifiers
CAS number 469-83-0
ATC code  ?
PubChem  ?
Chemical data
Formula C20H28O3 
Mol. mass 316.439 g/mol
Physical data
Melt. point 158–162 °C (316–324 °F)
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

Additional recommended knowledge

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Legal status

Legal everywhere

Routes Oral

Cafestol is a diterpene molecule present in coffee.

A typical bean of Coffea arabica contains about 0.6% cafestol by weight. Cafestol is present in highest quantity in unfiltered coffee drinks such as French press coffee or Turkish coffee. In filtered coffee drinks such as drip brewed coffee, it is present in only negligible amounts.

Studies have shown that regular consumption of boiled coffee increases serum cholesterol by 8% in men and 10% in women. For those drinking filter coffee, the effect was only significant for women.

Cafestol has also shown anticarcinogenic properties in rats.

According to a 2005 study by the Baylor College of Medicine, cafestol may act as an agonist ligand for the genes FXR and PXR, blocking cholesterol homeostasis.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cafestol". A list of authors is available in Wikipedia.
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