To use all functions of this page, please activate cookies in your browser.
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
Additional recommended knowledge
DeLisi was an early champion of the controversial idea that in cell biology, just as in the physical sciences, the mathematical formulation of concepts could predict phenomena that would not otherwise be apparent, and could thereby drive experimental research in new directions. The approach is seen in a number of investigations. His 1979 paper predicted, several years in advance of experimental demonstration, that the signal generated when nerve growth factor binds its plasma membrane receptor is transduced by receptor dimerization. In immunology, DeLisi was a strong proponent of the controversial hypothesis that the response of T-cells to antigenic stimulation involves formation of a ternary complex. Predictions based on the mathematical formulation of that idea, the amphipathic hypothesis, provided strong support for what was ultimately demonstrated conclusively by X-ray crystallogrphy. The mathematical methods, developed initially with Jay Berzofsky, were subsequently extended and modified by many others, presaging the now widely used bioinformatic approaches to guide the design of peptide vaccines. At the same time, the Section on Theoretical Immunology (STI), which DeLisi founded several years earlier at the NIH, had introduced the use of supervised learning algorithms for the identification of functional regions in DNA and proteins. The first database integrating DNA and protein sequences with analytical tools was developed in collaboration with Minoru Kanehisa, who was then a Visiting Fellow at STI.
In 1985, as Director of the U.S. Department of Energy’s (DOE) Health and Environmental Research Programs, DeLisi and his advisors proposed, planned and defended before the White House Office of Management and Budget and the Congress, the Human Genome Project. The proposal created a storm of controversy, but was included in President Ronald Reagan’s FY 1987 budget submission to the Congress, and subsequently passed both the House and the Senate, the latter with the essential support of Senator Pete Dominici (R, NM). In the spring of 1987, shortly before leaving the DOE, DeLisi established an ethical studies component of the Project. The goal was to set aside 3-5 % of the funding in order to engage the best minds in the humanities and social sciences: to develop a body of thought that would inform decisions about the development and deployment of the radically new technologies destined to emerge from the completion of the Project. In taking this step DeLisi was likely influenced by the fact that he was working for an agency that provided the vast majority of the Nation’s nuclear physics budget, and the awareness that the consequences of the rapid develop of nucelar energy some 4 decades earlier, continued to plague the planet. In addition to the technical and scientific advances engendered by the Human Genome Project, it and its progeny have had a profound affect on the sociology and culture of cell biology. The computer science community in particular moved with extraordinary dexterity into cell biology, transforming the field and creating a record of discovery destined to provide material for a remarkable story in the sociology of late 20th and early 21st Century science. Computational and mathematical methods are now widely viewed as central to progress in cell biology, a change that is forcing even the most conservative universities to respond to a new paradigm in biological education.
DeLisi is recipient of numerous awards including the Presidential Citizens Medal, awarded to him by President Clinton for his seminal role in initiating the Human Genome Project.
Charles DeLisi grew up in the Bronx, New York, going to New York public schools and living with his maternal grandparents. He then got a Bachelor's Degree in 1963 from CCNY and later continued his educational career at NYU, where he earned his PhD in physics. DeLisi later went on to make many achievements at several different college campuses as well as elsewhere. Some of these include being a post-doctoral fellow at Yale for three years and being hired as a Senior Lecturer in the Department of Engineering and Applied Sciences.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Charles_DeLisi". A list of authors is available in Wikipedia.|