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Clopamide



Clopamide
Systematic (IUPAC) name
4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-
benzamide
Identifiers
CAS number 636-54-4
ATC code C03BA03
PubChem 2804
Chemical data
Formula C14H20ClN3O3S 
Mol. mass 345.846 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Clopamide is a piperidine diuretic.

Additional recommended knowledge


Mechanism of Action of Clopamide: Clopamide is categorised as a thiazide like drug and works in similar way as the thiazide diuretics do. It acts at the Proximal Convoluted tubule site of the nephron where it inhibits the sodium-chloride cotransporter. Clopamide selectively binds at the chloride binding site of the sodium chloride cotransporter in the PCT cells on the luminal side and thus intereferes with the reabsorption of NaCl and thus causing an equiosmolar excretion of water along with NaCl.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Clopamide". A list of authors is available in Wikipedia.
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