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DNA laddering

DNA laddering is a phenomenon seen in laboratory tests; it is a sensitive indicator of programmed cell death, specifically of apoptosis.

Endonuclease activation is a characteristic feature of apoptosis. This degrades genomic DNA at internucleosomal linker regions and produces 180- to 185- base-pair DNA fragments. On agarose gel electrophoresis, these give a characteristic "laddered" appearance. The dying cell's morphological changes are short-lived and difficult to detect. DNA laddering has therefore become a sensitive method to distinguish apoptosis from ischemic or toxic cell death.[1]


  • M Iwata, D Myerson, B Torok-Storb and RA Zager (1996). An evaluation of renal tubular DNA laddering in response to oxygen deprivation and oxidant injury. Retrieved on 17 April, 2006.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "DNA_laddering". A list of authors is available in Wikipedia.
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