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Endonuclease activation is a characteristic feature of apoptosis. This degrades genomic DNA at internucleosomal linker regions and produces 180- to 185- base-pair DNA fragments. On agarose gel electrophoresis, these give a characteristic "laddered" appearance. The dying cell's morphological changes are short-lived and difficult to detect. DNA laddering has therefore become a sensitive method to distinguish apoptosis from ischemic or toxic cell death.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "DNA_laddering". A list of authors is available in Wikipedia.|