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David Adriaan van Dorp



David 'Davy' Adriaan van Dorp (Amsterdam April 27 1915 - Vlaardingen February 19 1995) was a Dutch chemist.

Additional recommended knowledge

Van Dorp was born as the son of Hendrik van Dorp and Maria van Dorp, and studied chemistry in Amsterdam where he received a PhD for his thesis Aneurine en gistphosphatase in 1941.

In 1946, while employed by the Dutch Organon company in Oss, Van Dorp and Jozef Ferdinand Arens ('Coco') published the synthesis for vitamin A acid in the scientific journal Nature. In 1947, they completed the first full synthesis for the complex compound vitamin A, by taking the final step and turning the acid in an alcohol. Their synthesis was not to be used for commercial production, as an alternative route that was published soon after by Otto Isler and co-workers (Hoffmann-La Roche) turned out to be much more suited for upscaling.

Van Dorp joined the Unilever Research Laboratory in Vlaardingen in 1959, and was a key person in the studies regarding the role of arachidonic acid in the metabolic pathway to prostaglandin E2, in close cooperation with Sune K. Bergström who would later receive a Nobel prize for his work on prostaglandins.

References

  • J.F. Arens, D.A. van Dorp, Nature 157, 190-191 (1946)
  • D.A. van Dorp, J.F. Arens, Nature 160, 189 (1947)
  • O. Isler, W. Huber, A. Ronco, M. Kofler, Helv. Chim. Acta 30, 1911-1927 (1947)
  • D.A. van Dorp, R.K. Beerthuis, D.H. Nugteren, H. Vonkeman, Biochim. Biophys. Acta 90, 204-207 (1964)
  • S. Bergström, H. Danielsson, B. Samuelsson, Biochim. Biophys. Acta 90, 207-210 (1964)
  • D.A. van Dorp, My years in lipid research, Journal of the American Oil Chemists' Society 60, 1645-1648 (1983)
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "David_Adriaan_van_Dorp". A list of authors is available in Wikipedia.
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