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Dexoxadrol



Dexoxadrol
Systematic (IUPAC) name
(2S)-2-[(4S)-2,2-di(phenyl)-1,3-dioxolan-4-yl]piperidine
Identifiers
CAS number 6495-46-1
ATC code  ?
PubChem 3034023
Chemical data
Formula C20H23NO2 
Mol. mass 309.40 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status

Legal

Routes  ?

Dexoxadrol (Dioxadrol) is a dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar effects to PCP in animals. Dexoxadrol, along with another related drug etoxadrol, were developed as analgesics for use in humans, but development was discontinued after patients reported side effects such as nightmares and hallucinations.[1][2]

Additional recommended knowledge



References

  1. ^ Sax M, Wunsch B. Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity. Current Topics in Medicinal Chemistry. 2006;6(7):723-32.
  2. ^ Aepkers M, Wunsch B. Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol. Bioorganic and Medicinal Chemistry. 2005 Dec 15;13(24):6836-49.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Dexoxadrol". A list of authors is available in Wikipedia.
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