Downregulated-in-adenoma

The Downregulated-in-adenoma (DRA) is an anion exchanger and a member (SLC26A3) of the sulfate anion transporter (SAT) family. It mediates Cl-HCO3 exchange and additionally transports sulfate and other anions at the apical membrane of enterocytes. The congenital absence of this membrane protein results in an autosomal recessive disorder, called congenital chloridorrhea or congenital chloride diarrhea (CLD). It is different from the anion exchanger (AE) that present in erythrocytes, renal tubule, and several other tissues.