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Doxazosin



Doxazosin
Systematic (IUPAC) name
[4-(4-amino-6,7-dimethoxy- quinazolin-2-yl) piperazin-1-yl]- (2,5-dioxabicyclo[4.4.0] deca-6,8,10-trien-4-yl) methanone
Identifiers
CAS number 74191-85-8
ATC code C02CA04
PubChem 3157
DrugBank APRD00474
Chemical data
Formula C23H25N5O5 
Mol. mass 451.475 g/mol
Pharmacokinetic data
Bioavailability 65%
Protein binding 98%
Metabolism Hepatic
Half life 22 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

℞ Prescription only

Routes oral

Doxazosin mesylate, a quinazoline compound sold by Pfizer under the brand name Cardura®, is an alpha blocker used to treat high blood pressure and benign prostatic hyperplasia.

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It is an alpha adrenergic receptor blocker which inhibits the binding of norepinephrine to alpha receptors in the autonomic nervous system. The primary effect of this blockage is relaxed vascular smooth muscle tone (vasodilation), which decreases peripheral vascular resistance, leading to decreased blood pressure.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Doxazosin". A list of authors is available in Wikipedia.
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