Doxazosin


Doxazosin
Systematic (IUPAC) name
[4-(4-amino-6,7-dimethoxy- quinazolin-2-yl) piperazin-1-yl]- (2,5-dioxabicyclo[4.4.0] deca-6,8,10-trien-4-yl) methanone
Identifiers
CAS number	74191-85-8
ATC code	C02CA04
PubChem	3157
DrugBank	APRD00474
Chemical data
Formula	C₂₃H₂₅N₅O₅
Mol. mass	451.475 g/mol
Pharmacokinetic data
Bioavailability	65%
Protein binding	98%
Metabolism	Hepatic
Half life	22 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	oral

Doxazosin mesylate, a quinazoline compound sold by Pfizer under the brand name Cardura®, is an alpha blocker used to treat high blood pressure and benign prostatic hyperplasia.

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It is an alpha adrenergic receptor blocker which inhibits the binding of norepinephrine to alpha receptors in the autonomic nervous system. The primary effect of this blockage is relaxed vascular smooth muscle tone (vasodilation), which decreases peripheral vascular resistance, leading to decreased blood pressure.

Category: Alpha blockers