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Their localization to the ER often depends on certain sequences of amino acids located at the N-terminal or C-terminal. The classical ER retention signal is the C-terminal KDEL sequence. These signals allow for retrieval from the Golgi apparatus, effectively maintaining the protein in the ER. Other mechanisms for ER retention are being studied but are not as well characterized as signal retention.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "ER_retention". A list of authors is available in Wikipedia.|