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Discovered in 1997, Erbin is a 200kDa protein containing a PDZ domain. Erbin's C-terminal PDZ domain is able to bind to ErbB2, a protein tyrosine kinase which is often associated with poor prognosis in epidermal oncogenesis. Erbin's N-terminal region has been shown to disrupt Ras to Raf binding and may be, through this action, a tumor suppressing protein.
Additional recommended knowledge
Erbin is named after its ability to bind ErbB2, though it shares a name with Saint Erbin, a 5th century Cornish monk. This has led some to suggest that Saint Erbin may be the patron saint of both PDZ domains and ErbB protein kinase receptors.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Erbin_(protein)". A list of authors is available in Wikipedia.|