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Five prime untranslated region
The five prime untranslated region (5' UTR), also known as the leader sequence, is a particular section of messenger RNA (mRNA) and the DNA that codes for it. It starts at the +1 position (where transcription begins) and ends just before the start codon (usually AUG) of the coding region. It usually contains a ribosome binding site (RBS), in bacteria also known as the Shine Dalgarno sequence (AGGAGGU). The 5' UTR may be a hundred or more nucleotides long, and the 3' UTR may be even longer (up to several kilobases in length) (Molecular Cell Biology, 5th edition, Lodish et al. p113, chapter 4.2).
Additional recommended knowledge
An mRNA molecule codes for a protein through translation. The mRNA also contains regions that are not translated: in eukaryotes this includes the 5' untranslated region, 3' untranslated region, 5' cap and poly-A tail.
In prokaryotic mRNA the 5' UTR is normally short. Some viruses and cellular genes have unusual long structured 5' UTRs which may have roles in gene expression.
Several regulatory sequences may be found in the 5' UTR:
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Five_prime_untranslated_region". A list of authors is available in Wikipedia.|