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Flavin containing amine oxidoreductase
Flavin containing amine oxidoreductases are a family of various amine oxidases, including maize polyamine oxidase (PAO), L-amino acid oxidases (LAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. In vertebrates MAO plays an important role in regulating the intracellular levels of amines via their oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidise spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.
Additional recommended knowledge
Human proteins containing this domain
AOF1; AOF2; IL4I1; MAOA; MAOB; PAOX; PPOX; SMOX;
This article includes text from the public domain Pfam and InterPro IPR002937
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Flavin_containing_amine_oxidoreductase". A list of authors is available in Wikipedia.|