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Fluacizine


Fluacizine
Systematic (IUPAC) name
3-diethylamino-1-[2-(trifluoromethyl) phenothiazin-10-yl]-propan-1-one
Identifiers
CAS number	30223-48-4
ATC code	?
PubChem	161562
Chemical data
Formula	C₂₀H₂₁F₃N₂O S
Mol. mass	394.455 g/mol
SMILES	search in eMolecules, PubChem
Synonyms	Flouracizine, Phtorazisin, ftoracizin, 10-(3-(Diethylamino)propionyl) -2-(trifluoromethyl)phenothiazine, 2-(Trifluoromethyl)-10- (N,N-diethyl-beta-alanyl)phenothiazine
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	℞-only(US)
Routes	Oral, intramuscular

Fluacizine (INN) is an antidepressant with sedative properties derived from phenothiazine.

Fluacizine possesses strong central and peripheral anticholinergic activity.

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1 Uses
- 1.1 Approved
2 Side effects
3 Contraindications

Uses

Approved

Fluacizine is indicated in bipolar depression, the emotional problems accompanying schizophrenia, anxiety accompanying depression, and for the depressive and extrapyramidal symptoms resulting from neuroleptic therapy. It is not effective for atypical depression or late-onset depression (once known as involutional melancholia).

Side effects

Side effects of fluacizine include feeling of weakness, nausea, and dry mouth.

Contraindications

Fluacizine is contraindicated in patients with liver or kidney impairment, enlarged prostate, peptic ulcer or who have taken MAOIs less than 14 days before starting therapy.

Categories: Antidepressants | Phenothiazines