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Forced degradation or accelerated degradation is a process whereby the natural degradation rate of a product or material is increased by the application of an additional stress.
Additional recommended knowledge
Forced degradation studies are used to identify reactions which may occur to degrade a processed product. Usually conducted before final formulation, forced degradation uses external stresses to rapidly screen material stabilities.
Longer term storage tests are usually used to measure similar properties when final formulations are involved because of the stringent FDA regulations. These tests are generally more expensive (because of the time involved) than forced degradation which is therefore used for rapid selection and elimination tests.
There are a number of common stresses which are used to
Chemical processes are often catalysed by the presence of acids and bases. The exposure of materials to these can therefore accelerate degradation reactions.
In accordance to arrhenius kinetics, increasing temperature increases the rate of any degradation process. Temperature is often used in conjunction with other stresses to increase reaction rates.
Standard methodologies include:
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Forced_degradation". A list of authors is available in Wikipedia.|