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GRB2-associated binding protein 2
Symbol GAB2
Entrez 9846
HUGO 14458
OMIM 606203
RefSeq NM_080491
UniProt Q9UQC2
Other data
Locus Chr. 11 q13.4-13.5

The GRB2-associated binding protein 2 or GAB2 gene encodes an adaptor protein serving as principal activator of Phosphatidylinositol 3-kinase. 10 SNPs of GAB2 gene have been found in one study to associate with risk of Alzheimer's disease in the carriers of ApoE4 allele.[1]


  1. ^ Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert RH, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Heward CB, Ravid R, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Kukull W, Papassotiropoulos A, Stephan DA (2007). "GAB2 Alleles Modify Alzheimer's Risk in APOE varepsilon4 Carriers" 54 (5): 713-720. doi:10.1016/j.neuron.2007.05.022. PMID 17553421. Free full text Free PDF Genetic data in the public domain
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "GAB2". A list of authors is available in Wikipedia.
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