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Gemfibrozil



Gemfibrozil
Systematic (IUPAC) name
5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid
Identifiers
CAS number 25812-30-0
ATC code C10AB04
PubChem 3463
DrugBank APRD00293
Chemical data
Formula C15H22O3 
Mol. mass 250.333 g/mol
Pharmacokinetic data
Bioavailability Close to 100%
Protein binding 95%
Metabolism Hepatic (CYP3A4)
Half life 1.5 hours
Excretion Renal 94%
Feces 6%
Therapeutic considerations
Pregnancy cat.

Category C

Legal status

By Prescription

Routes Oral

Gemfibrozil is the generic name for an oral drug used to lower lipid levels. It belongs to a group of drugs known as fibrates. It is most commonly sold as the brand name, Lopid. Other brand names include Jezil and Gen-Fibro.

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Therapeutic effects

Nontherapeutic effects and toxicities

  • GI distress
  • Musculoskeletal pain
  • Increased incidence of gallstones
  • Hypokalemia

Indications

Contraindications and Precautions

  • Gemfibrozil should not be given to these patients:
    • Hepatic dysfunction
    • Renal dysfunction
  • Gemfibrozil should be used with caution in these higher risk categories:
    • Biliary tract disease
    • pregnant women
    • obese patients
    • Native Americans

Drug Interactions

  • Anticoagulants. Gemfibrozil potentiates the action of coumadin and indanedione anticoagulants.
  • Lovastatin. Risk of myopathy when gemfibrozil is given to patients receiving lovastatin.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Gemfibrozil". A list of authors is available in Wikipedia.
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