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Systematic (IUPAC) name
CAS number 29110-47-2
ATC code C02AC02
PubChem 3519
DrugBank APRD00075
Chemical data
Formula C9H9Cl2N3O 
Mol. mass 246.093 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status

Prescription only

Routes  ?

Guanfacine (brand name Tenex, and the extended release Intuniv) is a centrally acting antihypertensive agent. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α-2 adrenergic receptors, which results in reduced sympathetic outflow leading to reduced vascular tone. Its adverse reactions include dry mouth, sedation, and constipation.


Guanfacine can be used to control high blood pressure. It works by reducing heart rate and relaxing blood vessels.   It is also sometimes prescribed as a treatment for attention-deficit hyperactivity disorder. (In August 2006, the makers of Guanfacine applied to the FDA to use this drug to treat ADHD In June 2007, the FDA approved Guanfacine for the use of ADHD treatment.[1])

Side effects

Usual: Dizziness, drowsiness, headache, constipation, gas pains, diarrhea, loss of appetite, fatigue, and nasal congestion may occur.

Rare: chest pain, shortness of breath, skin rash, swelling of the hands or feet, blurred vision, yellowing of the eyes or skin.

Others: mental/mood changes, tingling of the hands or feet, dry mouth, impotence, decreased sexual desire, vision changes, taste changes, ringing in the ears, leg cramps.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Guanfacine". A list of authors is available in Wikipedia.
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