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Guanine nucleotide exchange factor
Guanine nucleotide exchange factor (or guanine exchange protein) (GEFs) is implicated in addressing system of vesicular transport. For example, Rab is GDP bound and inactive in the cytosol before contact with GEF. The membrane bound GEF catalyses the removal of GDP and GDI (GDP dissociation inhibitor) and their replacement with GTP. This allows the Rab protein to bind budding vesicles (e.g. clathrin coated vesicles). Un-coating of the vesicle allows an interaction between Rab and Rab effector (at the target site) which aids SNARE protein interactions.
Examples of GEFs
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Guanine_nucleotide_exchange_factor". A list of authors is available in Wikipedia.|