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High-energy phosphate can mean one of two things:
Additional recommended knowledge
High-energy phosphate bonds are pyrophosphate bonds, acid anhydride linkages, formed by taking phosphoric acid derivatives and dehydrating them. As a consequence, the hydrolysis of these bonds is exothermic under physiological conditions, releasing energy.
The one exception is of value because it allows a single hydrolysis, ATP + 2H2O → AMP + PPi, to effectively supply the energy of hydrolysis of two high-energy bonds, with the hydrolysis of PPi being allowed to go to completion in a separate reaction. The AMP is regenerated to ATP in two steps, with the equilibrium reaction ATP + AMP ↔ 2ADP, followed by regeneration of ATP by the usual means, oxidative phosphorylation or other energy-producing pathways such as glycolysis.
Often, high-energy phosphate bonds are denoted by the character '~'. In this notation, ATP becomes A-P~P~P.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "High-energy_phosphate". A list of authors is available in Wikipedia.|