Hydroxyzine/reference table

User:James.Spudeman/drugref1

General classification
Antihistamine -- Competitive antagonist of histamine, H₁ histamine receptor and antiemetic, anxiolytic.
Prescriptive conditions
Alcohol withdrawal anxiety Anxiety manifested by organic disease states Nausea or nauseating conditions
Forms
Syrup Oral Suspension Tablet form Capsule form

Onset and duration
Oral administration onset: 15-30 minutes^[1] Suppression of wheal & flare response to allergenic skin extract: 4 days.^[2]
Serum level
Pruritus: 6-42 μg/L (14-102 nmol/L) (Suppresses pruritus in children)^[3]
Fate
Peak serum level Healthy adults -- 73 ± 11 μg/L occurs 2 ± 0.4 hr after a 0.7 mg/kg dose Primary biliary cirrhosis -- 117 ± 61 μg/L at 2.3 ± 0.7 hr after 44mg mean dose V_d Children -- 19 ±9 L/kg Healthy adults -- 16 ± 3 L/kg Elderly -- 23 ± 6 L/kg Primary biliary cirrhosis -- 23 ±13 L/kg Cl Children -- 1.9 L/hr/kg Healthy young/elderly adults -- 0.6 ± 0.2 L/hr/kg Primary biliary cirrhosis -- 0.5 ±0.4 L/hr/kg t_½ Children -- 7hr (increases with age) Healthy adults -- 20 ± 4 hr Elderly -- 29 ± 10 hr Primary biliary cirrhosis -- 37 ±13 hr

References

^ Usdin Yasuda S et al. Chlorpheniramine plasma concentration and histamine H₁-receptor occupancy. Clin Pharmacol Ther 1995;58:210-20.
^ Gendreau-Reid L et al. Comparison of the suppressive effect of astemizole, terfenadine, and hydroxyzine on histamine-induced wheals and flares in humans. J Allergy Clin Immunol 1986;77:335-40.
^ Simons FER et al. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis. J Pediatr1984;104:123μ7.