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Hypothetical protein

In biochemistry, a hypothetical protein is a protein whose existence has been predicted, but for which there is no experimental evidence that it is expressed in vivo.

The usual scenario involving a hypothetical protein is in gene identification during genome analysis. When the bioinformatic tool used for the gene identification finds a large open reading frame without an analog in the protein database, it returns "hypothetical protein" as an annotation remark.

The function of a hypothetical protein can also be predicted by domain homology searches with various confidence levels.



This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Hypothetical_protein". A list of authors is available in Wikipedia.
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