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Infrared multiphoton dissociation

Infrared multiphoton dissociation
Acronym IRMPD
Other Techniques
Related Blackbody infrared radiative dissociation
Electron capture dissociation
Collision-induced dissociation

Infrared multiphoton dissociation (IRMPD) is a technique used in mass spectrometry to fragment molecules in the gas phase usually for structural analysis of the original (parent) molecule. [1]

How it works

An infrared laser is directed through a window into the vacuum of the mass spectrometer where the ions are. The mechanism of fragmentation involves the absorption by a given ion of multiple infrared photons. The parent ion becomes excited into more energetic vibrational states until a bond(s) is broken resulting in gas phase fragments of the parent ion.

IRMPD is most often used in Fourier transform ion cyclotron resonance mass spectrometry.[2]

See also


  1. ^ Little DP, Speir JP, Senko MW, O'Connor PB, McLafferty FW (1994). "Infrared multiphoton dissociation of large multiply charged ions for biomolecule sequencing". Anal. Chem. 66 (18): 2809-15. PMID 7526742.
  2. ^ Laskin J, Futrell JH (2005). "Activation of large ions in FT-ICR mass spectrometry". Mass spectrometry reviews 24 (2): 135-67. doi:10.1002/mas.20012. PMID 15389858.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Infrared_multiphoton_dissociation". A list of authors is available in Wikipedia.
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