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A large region of DNA (greater than 3 KB) with a high degree uniformity in G-C and C-G (collectively GC) which tends to have more genes, higher local melting or denaturation temperatures, and different flexibility. Overall, Isochores are largely homogeneous in GC content in contrast to the heterogeneity of the entire genome.
Additional recommended knowledge
There are five families of isochores ranging in overall GC content:
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Isochore_(genetics)". A list of authors is available in Wikipedia.|