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Systematic (IUPAC) name
methyl propan-2-yl 2,6-dimethyl-4- (8-oxa-7,9-diazabicyclo[4.3.0] nona- 2,4,6,9- tetraen- 5-yl)- 1,4-dihydropyridine- 3,5-dicarboxylate
CAS number 75695-93-1
ATC code C08CA03
PubChem 3784
DrugBank APRD00298
Chemical data
Formula C19H21N3O5 
Mol. mass 371.387 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 95%
Metabolism  ?
Half life 8 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Isradipine (tradenames DynaCirc, Prescal) is a calcium channel blocker of the dihydropyridine class. It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack. More recent research suggests that isradipine may have potential uses for treating Parkinson's disease (Chan et al, 2007).

Further reading

    • Hattori T, Wang P (2006). "Calcium antagonist isradipine-induced calcium influx through nonselective cation channels in human gingival fibroblasts.". Eur J Med Res 11 (3): 93-6. PMID 16751108.
    • Ganz M, Mokabberi R, Sica D (2005). "Comparison of blood pressure control with amlodipine and controlled-release isradipine: an open-label, drug substitution study.". J Clin Hypertens (Greenwich) 7 (4 Suppl 1): 27-31. PMID 15858400.
    • Johnson B, Roache J, Ait-Daoud N, Wallace C, Wells L, Dawes M, Wang Y (2005). "Effects of isradipine, a dihydropyridine-class calcium-channel antagonist, on d-methamphetamine's subjective and reinforcing effects.". Int J Neuropsychopharmacol 8 (2): 203-13. PMID 15850499.
    • Fletcher H, Roberts G, Mullings A, Forrester T (1999). "An open trial comparing isradipine with hydralazine and methyl dopa in the treatment of patients with severe pre-eclampsia.". J Obstet Gynaecol 19 (3): 235-8. PMID 15512286.
    • C. Savio Chan, Jaime N. Guzman, Ema Ilijic, Jeff N. Mercer, Caroline Rick, Tatiana Tkatch, Gloria E. Meredith, D. James Surmeier (2007) Rejuvenation protects neurons in mouse models of Parkinson's disease. Nature. Nature advance online publication 10 June 2007 | doi:10.1038/nature05865
    This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Isradipine". A list of authors is available in Wikipedia.
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