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Ivanov reaction



The Ivanov reaction is the chemical reaction of the dianions of aryl acetic acids (Ivanov reagents) with electrophiles, primarily carbonyl compounds or isocyanates.[1][2][3][4] The reaction was named after the Bulgarian organic chemist, Dimitar Ivanov Popov, who discovered it.

Additional recommended knowledge

Ivanov reagents (dianions of aryl acetic acids) with react with many electrophiles, including aldehydes, ketones, isocyanates, and alkyl halides.[5] The product does not usually spontaneously decarboxylate, but it is possible with some reagents.

The Ivanov reaction is known to proceed through the Zimmerman-Traxler model transition state. Toulec et al. have investigated the reaction rates and kinetics.[6]

References

  1. ^  Ivanov, D.; Spassoff, A. Bull. Soc. Chim. France 1931, 49, 19 & 375.
  2. ^  Ivanov, D. et al. Bull. Soc. Chim. France 1932, 51, 1321 & 1325 & 1331.
  3. ^  Blagoev, B.; Ivanov, D. Synthesis 1970, 615-627. (Review)
  4. ^  Ivanov, D. Synthesis 1975, 83-98. (Review)
  5. ^  Hauser, C. R.; Dunnavant, W. R. (1960). "α,β-Diphenylpropionic acid". Organic Syntheses 40: 38.
  6. ^  Toullec, J.; Mladenova, M.; Gaudemar-Bardone, F.; Blagoev, B. J. Org. Chem. 1985, 50, 2563.

See also

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ivanov_reaction". A list of authors is available in Wikipedia.
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