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MAPEG family

Microsomal glutathione S-transferase 1
Symbol MAPEG
Pfam PF01124
InterPro IPR001129
SCOP 1iit
OPM family 199
OPM protein 2h8a
Available PDB structures:

2h8a; 2q7r; 2uuh

MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family of transmembrane proteins with highly divergent functions [1]. Included are the 5-lipoxygenase activating protein (gene FLAP), leukotriene C4 synthase (EC that catalyzes the production of leukotriene C4 (LTC4) from leukotriene A4 (LTA4) and microsomal glutathione S-transferase II (EC (GST-II) that also produces LTC4 from LTA4.

Another example is prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


  • 5-lipoxygenase-activating protein IPR001446

Human proteins containing this domain



  1. ^ Persson B, Jakobsson PJ, Morgenstern R, Mancini J, Ford-Hutchinson A (1999). "Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism". Protein Sci. 8 (3): 689-692. PMID 10091672.

This article includes text from the public domain Pfam and InterPro IPR001129

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "MAPEG_family". A list of authors is available in Wikipedia.
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