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A microreactor or microstructured reactor or microchannel reactor is a device in which chemical reactions take place in a confinement with typical lateral dimensions below 1 mm; the most typical form of such confinement are microchannels.[1] Microreactors are studied in the field of micro process engineering, together with other devices (such as micro heat exchangers) in which physical processes occur. The microreactor is usually a continuous flow reactor (contrast with/to a batch reactor). Microreactors offer many advantages over conventional scale reactors, including vast improvements in energy efficiency, reaction speed and yield, safety, reliability, scalability, on-site/on-demand production, and a much finer degree of process control.



Gas-phase microreactors have a long history but those involving liquids started to appear in the late 1990s.[1] One of the first microreactors with embedded high performance heat exchangers were made in the early 1990s by the Central Experimentation Department (Hauptabteilung Versuchstechnik, HVT) of Forschungszentrum Karlsruhe[citation needed] in Germany, using mechanical micromachining techniques that were a spinoff from the manufacture of separation nozzles for uranium enrichment[citation needed]. As research on nuclear technology was drastically reduced in Germany, microstructured heat exchangers were investigated for their application in handling highly exothermic and dangerous chemical reactions. This new concept, known by names as microreaction technology or micro process engineering, was further developed by various research institutions. An early example from 1997 involved that of azo couplings in a pyrex reactor with channel dimensions 90 micrometres deep and 190 micrometres wide.[1]


Using microreactors is somewhat different from using a glass vessel. These reactors may be a valuable tool in the hands of an experienced chemist or reaction engineer:

  • Microreactors typically have heat exchange coefficients of at least 1 megawatt per cubic meter per kelvin, up to 500 MW m-³ K-¹ vs. a few kilowatts in conventional glassware (1l flask ~10 kW m-³ K-¹)). Thus, microreactors can remove heat much more efficiently than vessels and even critical reactions such as nitrations can be performed safely at high temperatures[2]. Hot spot temperatures as well as the duration of high temperature exposition due to exothermicity decreases remarkably. Thus, microreactors may allow better kinetic investigations, because local temperature gradients affecting reaction rates are much smaller than in any batch vessel. Heating and cooling a microreactor is also much quicker and operating temperatures can be as low as -100 °C. As a result of the superior heat transfer, reaction temperatures may be much higher than in conventional batch-reactors. Many low temperature reactions as organo-metal chemistry can be performed in microreactors at temperatures of -10°C rather than -50°C to -78°C as in laboratory glassware equipment.
  • Microreactors are normally operated continuously. This allows the subsequent processing of unstable intermediates and avoids typical batch workup delays. Especially low temperature chemistry with reaction times in the millisecond to second range are no longer stored for hours until dosing of reagents is finished and the next reaction step may be performed. This rapid work up avoids decay of precious intermediates and often allows better selectivities [3].
  • Continuous operation and mixing causes a very different concentration profile when compared with a batch process. In a batch, reagent A is filled in and reagent B is slowly added. Thus, B encounters initially a high excess of A. In a microreactor, A and B are mixed nearly instantly and B will be NOT exposed to a large excess of A. This may be an advantage or disadvantage depending on the reaction mechanism - it is important to be aware of such different concentration profiles.
  • Although a bench-top microreactor can synthesize chemicals only in small quantities, scale-up to industrial volumes is simply a process of multiplying the number of microchannels. In contrast, batch processes too often perform well on R&D bench-top level but fail at batch pilot plant level [4].
  • Pressurisation of materials within microreactors (and associated components) is generally easier than with traditional batch reactors. This allows reactions to be increased in rate by raising the temperature beyond the boiling point of the solvent. This, although typical Arrhenius behaviour, is more easily facilitated in microreactors and should be considered a key advantage. Pressurisation may also allow dissolution of reactant gasses within the flow stream.


  • Although there have been reactors made for handling particles, microreactors generally do not tolerate particulates well, often clogging. Clogging has been identified by a number of researchers as the biggest hurdle for microreactors being widely accepted as a beneficial alternative to batch reactors. Gas evolved may also shorten the residence time of reagents by pushing out material much faster than anticipated (though the application of backpressure can solve this issue).
  • Pumping by mechanical pumping may generate a pulsating flow which can be disadvantageous. Much work has been devoted to development of low pulse or pulseless pumps. A continuous flow solution is electroosmotic flow (EOF).
  • Typically, reactions performing very well in a microreactor encounter many problems in vessels, especially when scaling up. Microreactors are well suitable for fast and exothermic reactions (traditional semi-batch application) but cause trouble as soon as particles (i.e. unsoluble/unexpected side-products) are involved.

T reactors

One of the simplest forms of a microreactor is a 'T' reactor. A 'T' shape is etched into a plate with a depth that may be 40 micrometres and a width of 100 micrometres: the etched path is turned into a tube by sealing a flat plate over the top of the etched groove. The cover plate has three holes that align to the top-left, top-right, and bottom of the 'T' so that fluids can be added and removed. A solution of reagent 'A' is pumped into the top left of the 'T' and solution 'B' is pumped into the top right of the 'T'. If the pumping rate is the same, the components meet at the top of the vertical part of the 'T' and begin to mix and react as they go down the trunk of the 'T'. A solution of product is removed at the base of the 'T'.




Microreactors can be used to synthesise material more effectively than current batch techniques allow. The benefits here are primarily enabled by the mass transfer, thermodynamics, and high surface area to volume ratio environment as well as engineering advantages in handling unstable intermediates. Microreactors are applied in combination with photochemistry, electrosynthesis, multicomponent reactions and polymerization (for example that of butyl acrylate). It can involve liquid-liquid systems but also solid-liquid systems with for example the channel walls coated with a heterogeneous catalyst. Synthesis is also combined with online purification of the product.[1]

In one microreactor study a Knoevenagel condensation[5] was performed with the channel coated with a zeolite catalyst layer which also serves to remove water generated in the reaction:

A Suzuki reaction was examined in another study[6] with a palladium catalyst confined in a polymer network of polyacrylamide and a triarylphosphine formed by interfacial polymerization:

The combustion of propane was demonstrated to occur at temperatures as low as 300­°C in a microchannel setup filled up with an aluminum oxide lattice coated with a platinum / molybdenum catalyst:[7]


Microreactors can also enable experiments to be performed at a far lower scale and far higher experimental rates than currently possible in batch production, while not collecting the physical experimental output. The benefits here are primarily derived from the low operating scale, and the integration of the required sensor technologies to allow high quality understanding of an experiment. The integration of the required synthesis, purification and analytical capabilities is impractical when operating outside of a microfluidic context.

Academic research

Microreactors, and more generally, micro process engineering, are the subject of worldwide academic research. A prominent recurring conference is IMRET, the International Conference on Microreaction Technology. Microreactors and micro process engineering have also been featured in dedicated sessions of other conferences, such as the Annual Meeting of the American Institute of Chemical Engineers (AIChE), or the International Symposia on Chemical Reaction Engineering (ISCRE). Research is now also conducted at various academic institutions around the world, e.g. at the Massachusetts Institute of Technology (MIT) in Cambridge/MA, University of Illinois Urbana-Champaign, and at Oregon State University in Corvallis/OR in the United States, at the EPFL in Lausanne, Switzerland, at Eindhoven University of Technology in Eindhoven and at Radboud University Nijmegen in Nijmegen, Netherlands and at the LIPHT [1] of Université Louis Pasteur in Strasbourg, France.

Market structure

Depending on the application focus, there are various hardware suppliers and commercial development entities to service the evolving market. One view to technically segment market, offering and market clearing stems from the scientific and technological objective of market agents:

(a) Ready to Run (turnkey) systems are being used where the application environment stands to benefit from new chemical synthesis schemes, enhanced investigational throughput of up to approximately 10 - 100 experiments per day (depends on reaction time) and reaction subsystem, and actual synthesis conduct at scales ranging from 10 milligrams per experiment to triple digit tons per year (continuous operation of a reactor battery).

(b) Modular (open) systems are serving the niche for investigations on continuous process engineering lay-outs, where a measurable process advantage over the use of standardized equipment is anticipated by chemical engineers. Multiple process lay-outs can be rapidly assembled and chemical process results obtained on a scale ranging from several grams per experiment up to approximately 100 kg at a moderate number of experiments per day (3-15). A secondary transfer of engineering findings in the context of a plant engineering exercise (scale-out) then provides target capacity of typically single product dedicated plants. This mimics the success of engineering contractors for the petro-chemical process industry.

(c) Dedicated developments. Manufacturer of microstructured components are mostly commercial development partners to scientists in search of novel synthesis technologies. Such development partners typically excel in the set-up of comprehensive investigation and supply schemes, to model a desired contacting pattern or spatial arrangement of matter. To do so they predominantly offer information from proprietary integrated modeling systems that combine computational fluid dynamics with thermokinetic modelling. Moreover, as a rule, such development partners establish the overall application analytics to the point where the critical initial hypothesis can be validated and further confined.

R&D Centers

  • Institut für Mikrotechnik Mainz GmbH
  • Forschungszentrum Karlsruhe GmbH


  1. ^ a b c d Recent advances in synthetic micro reaction technology Paul Watts and Charlotte Wiles Chem. Commun., 2007, 443 - 467, doi:10.1039/b609428g
  2. ^ D.Roberge, L.Ducry, N.Bieler, P.Cretton, B.Zimmermann, Chem. Eng. Tech. 28 (2005) No. 3, online available
  3. ^ T.Schwalbe, V.Autze, G.Wille: Chimica 2002, 56, p.636, see also Microflow Synthesis
  4. ^ T.Schwalbe, V.Autze, M. Hohmann, W. Stirner: Org.Proc.Res.Dev 8 (2004) p. 440ff, see also Continuous process research and implementation from laboratory to manufacture
  5. ^ Knoevenagel condensation reaction in a membrane microreactor Sau Man Lai, Rosa Martin-Aranda and King Lun Yeung Chem. Commun., 2003, 218 - 219, doi:10.1039/b209297b
  6. ^ Instantaneous Carbon-Carbon Bond Formation Using a Microchannel Reactor with a Catalytic Membrane Yasuhiro Uozumi, Yoichi M. A. Yamada, Tomohiko Beppu, Naoshi Fukuyama, Masaharu Ueno, and Takehiko Kitamori J. Am. Chem. Soc.; 2006; 128(50) pp 15994 - 15995; (Communication) doi:10.1021/ja066697r
  7. ^ Low temperature catalytic combustion of propane over Pt-based catalyst with inverse opal microstructure in a microchannel reactor Guoqing Guan, Ralf Zapf, Gunther Kolb, Yong Men, Volker Hessel, Holger Loewe, Jianhui Ye and Rudolf Zentel Chem. Commun., 2007, 260 - 262, doi:10.1039/b609599b
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Microreactor". A list of authors is available in Wikipedia.
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