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Mitochondrial apoptosis-induced channel
MAC, the Mitochondrial Apoptosis-Induced Channel, is an early marker of the onset of apoptosis. This ion channel is formed on the outer mitochondrial membrane in response to certain apoptotic stimuli. MAC activity is detected by patch clamping mitochondria from apoptotic cells at the time of cytochrome c release.
Additional recommended knowledge
Members of the Bcl-2 protein family regulate apoptosis by controlling the formation of MAC: the pro-apoptotic members Bax and/or Bak form MAC, whereas the anti-apoptotic members like Bcl-2 or Bcl-xL prevent MAC formation. Once formed, MAC mediates the release of cytochrome c to the cytosol, triggering the commitment step of the mitochondrial apoptotic cascade.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mitochondrial_apoptosis-induced_channel". A list of authors is available in Wikipedia.|