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N-Acetyl procainamide

N-Acetyl procainamide
Systematic (IUPAC) name
CAS number 32795-44-1
ATC code  ?
PubChem 4342
Chemical data
Formula C15H23N3O2 
Mol. mass 277.36 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes intravenously or orally

N-Acetylprocainamide (NAPA) (or acecainide) is the N-acetylated metabolite of procainamide. It is a Class III antiarrhythmic agent.

It can be given either intravenously or orally, and is eliminated primarily by renal excretion. Comparative studies with other antiarrhythmic drugs have not been undertaken apart from a small study in atrial flutter where acecainide was better than quinidine plus digoxin. Thus, although further clinical experience is required before the relative place of acecainide in therapy can be determined, the drug nevertheless appears to offer advantages over procainamide, particularly with respect to the reduced formation of antinuclear antibodies.


  • Merck Index, 13th Edition, 20.
  • Ger. Pat. , 1971, 2 062 978; CA , 75 , 76427, (Acecainide)

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "N-Acetyl_procainamide". A list of authors is available in Wikipedia.
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