To use all functions of this page, please activate cookies in your browser.
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
Neddylation is the process by which the ubiquitin like protein Nedd8 is conjugated to its target proteins. This process is analogous to ubiquitination, although relies on its own E1 and E2 enzymes. No Nedd8 specific E3 has yet been identified and it is possible that the Neddylation system relies on E3 ligases with dual specificity.
Additional recommended knowledge
Neddylation is involved in the pathogenesis of Alzheimer's Disease where its activation seems to drive neurons into apoptosis by initiating cell cycle reentry.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Neddylation". A list of authors is available in Wikipedia.|