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Symbol NGB
Entrez 58157
HUGO 6553
OMIM 605304
UniProt Q9NPG2
Other data
Locus Chr. 14 q24

Neuroglobin is a member of the vertebrate globin family involved in cellular oxygen homeostasis. It is an intracellular hemoprotein expressed in the central and peripheral nervous system, cerebrospinal fluid, retina and endocrine tissues. Neuroglobin is a monomer that reversibly binds oxygen with an affinity higher than that of hemoglobin. It also increases oxygen availability to brain tissue and provides protection under hypoxic or ischemic conditions, potentially limiting brain damage. It is of ancient evolutionary origin, and is homologous to nerve globins of invertebrates.

Neuroglobin was first identified by Thorsten Burmester et al. in 2000[1]. Italian researchers suggest[1] that neuroglobin is more likely to usher in nitric oxide to protect neuron survival and recovery in areas where oxygen supply is reduced.

See also


  1. ^ Burmester, T.; Weich, B.; Reinhardt, S.; Hankeln, T. A vertebrate globin expressed in the brain. Nature 407: 520-523, 2000.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Neuroglobin". A list of authors is available in Wikipedia.
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