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The Overman rearrangement is a chemical reaction that can be described as a Claisen rearrangement of allylic alcohols to give allylic trichloroacetamides through an imidate intermedate. The Overman rearrangement was discovered in 1974 by Larry Overman.
Additional recommended knowledge
The [3,3]-sigmatropic rearrangement is diastereoselective and can be catalyzed by heat, Hg(II), or Pd(II). The resulting allylamine structures can be transformed into many chemically and biologically important natural and un-natural amino acids (like (1-adamantyl)glycine).
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Overman_rearrangement". A list of authors is available in Wikipedia.|