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P53 upregulated modulator of apoptosis

BCL2 binding component 3
Symbol(s): BBC3
Other names:JFY1, PUMA
Genetic data
Locus: Chr. 19 q13.3
Database Links
Entrez: 27113
OMIM: 17868
RefSeq: NM_014417
UniProt: Q9BXH1

The p53 upregulated modulator of apoptosis, or PUMA, is a pro-apoptotic member of the Bcl-2 protein family.[1] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of PUMA is regulated by the tumor suppressor p53, and PUMA has been shown to be involved in p53-mediated apoptosis.

See also


  1. ^ Nakano, K.; and Vousden, K. H. (March 2001). "PUMA, a Novel Proaptotic Gene, is Induced by p53". Molecular Cell 7: 683-694.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "P53_upregulated_modulator_of_apoptosis". A list of authors is available in Wikipedia.
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