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PROSITE is a database of protein families and domains. It consists of documentation entries describing protein domains, families and functional sites as well as associated patterns and profiles to identify them. These are manually curated by a team of the Swiss Institute of Bioinformatics and tightly integrated into Swiss-Prot protein annotation. PROSITE was created in 1988 by Amos Bairoch.
Additional recommended knowledge
Its uses include identifying possible functions of newly-discovered proteins and analysis of known proteins for previously undetermined activity. PROSITE offers tools for sequence analysis and motif detection (see sequence motif). It is part of the ExPASy proteomics analysis servers.
The database ProRule builds on the domain descriptions of PROSITE. It provides additional information about functionally and/or structurally critical amino acids. The rules contain information about biologically meaningful residues, like active sites, binding sites, post-translational modification sites or disulfide bonds, to help function determination. These can automatically generate annotation based on PROSITE motifs.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "PROSITE". A list of authors is available in Wikipedia.|