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Phospholipidosis is a lipid storage disorder in which excess phospholipids accumulate within cells. Drug-induced phospholipidosis is an adverse drug reaction that occurs with many cationic amphiphillic drugs. While the mechanism is not truly understood, four possible mechanisms have been proposed, outlined below:
Additional recommended knowledge
A major concern for drug regulatory agencies is drug-induced phospholipidosis occurring in hepatocytes, kidneys, and lungs, which causes failure of liver, kidney, and respiratory function.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Phospholipidosis". A list of authors is available in Wikipedia.|