To use all functions of this page, please activate cookies in your browser.
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
The Pribnow box (also known as the Pribnow-Schaller box) is the sequence TATAAT of six nucleotides (thymine-adenine-thymine-etc.) that is an essential part of a promoter site on DNA for transcription to occur in prokaryotes. It is an idealized or consensus sequence - that is, it shows the most frequently occcuring base at each position in a large number of promoters analyzed; individual promoters often vary from the consensus at one or more positions. It is also commonly called the -10 sequence, because it is centered roughly 10 base pairs upstream from the site of initiation of transcription.
Additional recommended knowledge
The Pribnow box has a function similar to the TATA box that occurs in promoters in eukaryotes: it is recognized and bound by a subunit of RNA polymerase during initiation of transcription. This region of the DNA is also the first place where base pairs separate to allow access to one strand as the template for transcription. The AT-richness is important to allow this separation, since adenine and thymine pair together with only two hydrogen bonds (as opposed to three as with guanine and cytosine), they are easier to break apart.
Probability of occurrence of each nucleotide
The Pribnow box or Pribnow-Schaller box is named after David Pribnow and Heinz Schaller.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Pribnow_box". A list of authors is available in Wikipedia.|